This easy cheeseburger casserole recipe is the perfect busy weeknight meal. Ground beef, spices, and cheese are topped with biscuits to create a hearty casserole that the whole family will love!
Cheeseburgers may just be our favorite dinner around here, and with our popular cheeseburgers in the oven recipe, I knew you’d love this casserole too! But if you’re a cheeseburger fan, you may also love our cheeseburger sliders and these cheeseburger subs, which are hard to beat!

Swap out the seasoning and make yourself a Big Mac Casserole for that iconic Golden Arches experience. You can also make Cheeseburger Sliders for more of a grab-and-go meal.
Why You’ll Love This Recipe
So of course this easy cheeseburger casserole goes right to the top of my list of favorite casseroles! (Well, along with this french onion beef casserole and this Doritos chicken casserole of course.)
Most hamburger casserole recipes have some sort of meat sauce/noodle mixture, so I was super excited when I could share a cheeseburger casserole without pasta! (Much like this walking taco casserole too!)
You’ll also love this similar hashbrown hamburger casserole, classic beef stroganoff recipe, and this chicken pot pie casserole!
[feast_advanced_jump_to]Ingredients
This recipe uses simple ingredients that even your picky eaters will be ok with!
- 2 pounds ground beef (See our other ground beef recipes.)
- ⅔ cup ketchup
- 2 teaspoons onion powder
- ½ teaspoon garlic powder
- ½ teaspoon black pepper
- 3 cups cheddar cheese shredded and divided
- 1 can refrigerated biscuits like Pillsbury Grands
- 1 tablespoon salted butter melted
Jump to the printable recipe card right now or keep scrolling to see how you can make this easy recipe (where we basically create a cheeseburger in casserole form)!

Instructions
- Heat oven to 425° F. Grease a 9×13 casserole dish or spray it with cooking spray.
- Brown ground beef in a large skillet over medium-high heat (breaking it up with a wooden spoon as you go) until no longer pink; drain off fat. If you are using extra-lean ground beef (or turkey), you can put a bit of olive oil in the pan to keep it from sticking.


- Add ketchup, onion powder, garlic powder, ½ teaspoon pepper, and 2 cups of shredded cheese. Stir well to combine.

- Scoop mix into the prepared 9×13″ baking dish and spread evenly. Top beef mixture with remaining one cup of cheese.
- Split 6 biscuits in half through the middle so you’ve got 12 thin rounds. Splitting them keeps the biscuit layer from staying doughy underneath. Lay the tops and bottoms over the casserole in a single layer, covering as much as you can. If your can came with extras, set them aside for another use.


- Arrange biscuits on top of the casserole (should fit 12 biscuits).

- Bake for 10 to 15 minutes or until biscuits are golden brown and cooked through.

- Brush melted butter on top of the biscuits and serve.

Substitutions
What substitutions can you make in this baked cheeseburger casserole? Quite a few actually!
- Beef – you can replace this with ground turkey, pork or really any other ground meat.
- Cheese – you could use other American cheese in place of cheddar, or even a soft cheese like Velveeta.
- Biscuits – if you don’t have any refrigerated biscuits on hand, you can make boxed biscuits or biscuits from scratch and drop them by the teaspoon full on top of the casserole instead.
- Spices – you could use fresh chopped onion and garlic in place of the dried spices called for in this recipe.
- Ketchup – you can use tomato sauce (or tomato paste thinned out with a bit of water) in place of the ketchup in this recipe to reduce the sugar content a bit.

Variations
If you’ve made this casserole and you loved it, try one of these variations the next time you make it!
- Spice It Up – if you like Mexican recipes or spicy food in general, try replacing the ketchup in this recipe with a spicy salsa and the cheddar cheese with a pepper jack cheese!
- Bacon cheeseburger casserole – chop some bacon and cook it at the same time as your ground beef to turn this into a bacon cheeseburger casserole. You could also add some crumbled bacon to the cheese you put on top of the meat mixture! (Some of these ingredients are similar to our tater tot casserole too!)
- Sour Cream and Onion – if you want to get really wild, try mixing some chopped green onions and crushed sour cream and onion potato chips in with the cheese. Then serve your sour cream and onion cheesy casserole with a dollop of sour cream on top!

Storage
STORAGE: Store in an airtight container in the refrigerator for up to three days.
Expert Tips and FAQs
This is not only a great recipe because it’s delicious but also because it’s so flexible! You can mix in basically anything you like to make this casserole exactly how your entire family wants it to be.
– Cook up some chopped bacon with the ground beef if you like.
– Add in some vegetables or cauliflower rice to give it a nutritional boost.
– Mix in some red pepper flakes or chili powder to give it a kick. – If you aren’t on a keto diet, you could boil some elbow macaroni in a large pot of salted water, drain it and add it to the meat mixture, too!
Yes, you sure can. The only change we would make is to be sure you put this in a freezer safe container. We would suggest an aluminum 9×13 pan if you are going to freeze it.
When you are ready to cook it, let the casserole thaw in the fridge for 24 hours and then cook according to the recipe instructions.
You’ll use 6 biscuits, split in half to make 12 thin rounds. Splitting them helps the topping cook all the way through instead of staying doughy underneath. Biscuit cans come in different counts, so if yours has a couple extras, just save them for another meal.
What to Serve with Cheeseburger Casserole
Wondering what to serve with cheeseburger casserole? We think it would go great with our easy side salad (there’s a secret that makes this one THE BEST one ever)!
Or, you can serve this with crack green beans and candied carrots.
Related Recipes
If you’re looking for more easy dinner recipes check out our other ground beef recipes like this homemade hamburger helper in the instant pot or this 30 minute taco pasta recipe! Or, similar ingredients come together to make a creamy stovetop dinner in this hamburger mac and cheese!
Recipe
Cheeseburger Casserole
Ingredients
- 2 pounds ground beef
- ⅔ cup ketchup
- 2 teaspoons onion powder
- ½ teaspoon garlic powder
- ½ teaspoon black pepper
- 3 cups cheddar cheese shredded and divided
- 1 can refrigerated biscuits like Pillsbury Grands
- 1 tablespoon salted butter melted
Instructions
- Heat oven to 425° F. Grease a 9×13 casserole dish or spray it with cooking spray.
- Brown ground beef in a large skillet over medium-high heat (breaking it up as you go) until no longer pink; drain off fat. If you are using extra-lean ground beef (or turkey), you can put a bit of olive oil in the pan to keep it from sticking.
- Add ketchup, onion powder, garlic powder, ½ teaspoon pepper, and 2 cups of shredded cheese. Stir well to combine.
- Scoop mix into the prepared 9×13" baking dish and spread evenly. Top beef mixture with remaining one cup of cheese.
- Split 6 biscuits in half through the middle so you've got 12 thin rounds. Splitting them keeps the biscuit layer from staying doughy underneath. Lay the tops and bottoms over the casserole in a single layer, covering as much as you can. If your can came with extras, set them aside for another use.
- Arrange biscuits on top of the casserole (should fit 12 biscuits).
- Bake for 10 to 15 minutes or until biscuits are golden brown and cooked through.
- Brush melted butter on top of the biscuits and serve.


















































































































































































































































































































































































































































































































